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pentobarbital will lower the level or influence of buprenorphine, prolonged-performing injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Sufferers who transfer to buprenorphine prolonged-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers needs to be monitored to mak